Table 4.

Association of genotypes and hot flashes, adjusted OR with 95% CI

Gene variant	Variant vs. reference genotype comparison	European-Americans		African-Americans
		HF	Moderate and severe HF	HF	Moderate and severe HF
COMT Val158Met	+/+, +/− vs. −/−	0.71 (0.31–1.60)	1.21 (0.48–3.04)	1.30 (0.59–2.88)	1.44 (0.67–3.09)
	+/− vs. −/−	0.63 (0.23–1.69)	1.17 (0.45–3.09)	0.97 (0.42–2.23)	1.03 (0.45–2.37)
	+/+ vs. −/−	0.75 (0.32–1.79)	1.30 (0.44–3.84)	6.67 (0.80–55.67)	4.20 (1.13–15.59)a
CYP3A4*1B	+/+, +/− vs. −/−	1.33 (0.38–4.70)	0.68 (0.16–2.86)	1.10 (0.39–3.13)	1.09 (0.39–3.04)
	+/− vs. −/−	1.06 (0.28–4.0)	0.42 (0.08–2.21)	1.31 (0.42–4.06)	1.03 (0.39–3.53)
	+/+ vs. −/−	b	b	0.91 (0.29–2.82)	1.17 (0.39–3.53)
CYP1A2*1F	+/+, +/− vs. −/−	0.96 (0.32–2.88)	1.60 (0.41–6.18)	1.00 (0.32–3.10)	1.69 (0.53–5.43)
	+/− vs. −/−	1.47 (0.45–4.85)	1.72 (0.42–7.13)	1.31 (0.39–4.39)	1.91 (0.56–6.58)
	+/+ vs. −/−	0.77 (0.24–2.42)	1.50 (0.37–6.07)	0.77 (0.23–2.56)	1.49 (0.43–5.16)
CYP1B1*3	+/+, +/− vs. −/−	1.18 (0.58–2.42)	0.88 (0.41–1.91)	2.24 (0.49–10.24)	6.57 (0.73–58.82)
	+/− vs. −/−	1.18 (0.56–2.51)	0.82 (0.36–1.86)	1.38 (0.61–13.89)	5.34 (0.80–51.40)
	+/+ vs. −/−	1.18 (0.42–3.30)	1.10 (0.37–3.31)	2.92 (0.61–13.89)	7.25 (0.79–65.89)
CYP1B1*4	+/+, +/− vs. −/−	1.39 (0.66–2.92)	0.77 (0.35–1.79)	0.11 (0.02–0.48)c	0.51 (0.79–65.89)
	+/− vs. −/−	1.38 (0.64–2.94)	0.82 (0.36–1.88)	0.11 (0.02–0.48)	0.51 (0.79–65.89)
	+/+ vs. −/−	1.70 (0.09–33.51)	b	b	b

Odds ratios adjusted for age, BMI, alcohol consumption, and menopausal stage.

^aP = 0.03.

^bEstimate uninterpretable due to insufficient data.

^cP = 0.003.