Table 6.
Hot flashes in smokers by genotype, African-Americans
| Any hot flashes (n) |
Adjusted OR of hot flashes in smokers (95% CI) | Moderate or severe hot flashes (n) |
Adjusted OR of moderate or severe hot flashes in smokers (95% CI) | |||
|---|---|---|---|---|---|---|
| + | − | + | − | |||
| SNP COMT Val158Met | ||||||
| −/− | 37 | 20 | 0.95 (0.29–3.08) | 20 | 37 | 1.99 (0.62–6.46) |
| +/− | 40 | 21 | 2.89 (0.74–11.25) | 24 | 37 | 1.78 (0.52–0.61) |
| +/+ | 13 | 2 | a | 10 | 5 | 1.11 (0.1–12.17) |
| Pint− | Pint = 0.9 | |||||
| CYP3A4*1B | ||||||
| −/− | 14 | 7 | 0.64 (0.09–4.34) | 8 | 13 | 0.76 (0.11–5.06) |
| +/− | 42 | 17 | 1.83 (0.48–7.02) | 23 | 36 | 2.14 (0.62–7.34) |
| +/+ | 35 | 20 | 3.35 (0.86–13.11) | 24 | 31 | 2.51 (0.74–8.55) |
| Pint = 0.4 | Pint = 0.6 | |||||
| CYP1A2*1F | ||||||
| −/− | 12 | 7 | 1.13 (0.13–9.97) | 5 | 14 | 0.64 (0.07–6.19) |
| +/− | 49 | 17 | 6.16 (1.11–33.91) | 30 | 36 | 2.67 (0.82–8.70) |
| +/+ | 31 | 20 | 0.88 (0.25–3.15) | 20 | 31 | 1.78 (0.5–6.39) |
| Pint = 0.2 | Pint = 0.5 | |||||
| CYP1B1*3 | ||||||
| −/− | 4 | 4 | a | 1 | 7 | a |
| +/− | 30 | 19 | a | 19 | 30 | a |
| +/+ | 58 | 21 | a | 35 | 44 | a |
| Pint− | Pint− | |||||
| CYP1B1*4 | ||||||
| −/− | 88 | 35 | 1.71 (0.67–4.36) | 52 | 71 | 1.86 (0.81–4.26) |
| +/− | 4 | 9 | 2.35 (0.12–46.80) | 3 | 10 | 2.6 (0.13–51.81) |
| +/+ | 0 | 2 | a | 0 | 2 | a |
| Pint = 0.9 | Pint = 0.9 | |||||
Adjusted for age, BMI, alcohol consumption, and menopausal stage. Pint is the P value for significance of interaction between smoking and genotype status. Pint− indicates that the P value for interaction could not be calculated.
a
Estimate uninterpretable due to insufficient data.