Table 2.
Genotype distributions and OR estimates for DTC, pooled, non-Hispanic whites only and by study center
| ATM SNP ID | Genotype | Inheritance modela | Pooled population |
Non-Hispanic Whites |
SUC population |
UTMDACC population |
||||
|---|---|---|---|---|---|---|---|---|---|---|
| No. of cases/controls | Adjusted OR (95% CI)b | No. of cases/controls | Adjusted OR (95% CI)b | No. of cases/controls | Adjusted OR (95% CI)b | No. of cases/controls | Adjusted OR (95% CI)b | |||
| rs228589 | TT | Dominant | 227/294 | 1.0 | 178/241 | 1.0 | 116/126 | 1.0 | 111/168 | 1.0 |
| TA/AA | 363/587 | 0.8 (0.6–1.0) | 280/441 | 0.9 (0.7–1.1) | 173/244 | 0.8 (0.6–1.1) | 190/343 | 0.8 (0.6–1.1) | ||
| rs189037 | AA | Dominant | 215/277 | 1.0 | 170/233 | 1.0 | 105/112 | 1.0 | 110/165 | 1.0 |
| AG/GG | 375/606 | 0.8 (0.6–1.0) | 288/452 | 0.9 (0.7–1.1) | 184/260 | 0.8 (0.5–1.1) | 191/346 | 0.8 (0.6–1.1) | ||
| rs1800054 | CC | 576/868 | 1.0 | 445/671 | 1.0 | 280/369 | 1.0 | 296/499 | 1.0 | |
| CG | 16/16 | 1.6 (0.8–3.4) | 14/14 | 1.5 (0.7–3.4) | 9/4 | 3.6 (0.9–14.1) | 7/12 | 1.0 (0.4–2.7) | ||
| rs4986761 | TT | 574/860 | 1.0 | 441/668 | 1.0 | 277/363 | 1.0 | 297/497 | 1.0 | |
| TC | 18/22 | 1.2 (0.6–2.4) | 18/15 | 1.8 (0.9–3.7) | 12/8 | 1.9 (0.7–5.1) | 6/14 | 0.8 (0.3–2.1) | ||
| rs1800057 | CC | Dominant | 550/844 | 1.0 | 425/655 | 1.0 | 271/355 | 1.0 | 279/489 | 1.0 |
| CG/GG | 36/32 | 1.9 (1.1–3.1) | 29/25 | 1.8 (1.0–3.1) | 17/11 | 2.3 (1.0–5.6) | 19/21 | 1.6 (0.9–3.1) | ||
| rs1801516 | GG | Dominant | 483/697 | 1.0 | 366/519 | 1.0 | 244/305 | 1.0 | 239/392 | 1.0 |
| GA/AA | 109/188 | 0.9 (0.7–1.1) | 93/167 | 0.8 (0.6–1.1) | 45/69 | 0.8 (0.5–1.2) | 64/119 | 0.9 (0.6–1.3) | ||
SUC, State University of Campinas; UTMDACC, University of Texas MD Anderson Cancer Center. P < 0.05 is shown in bold.
a
The best model of inheritance for each SNP was determined using Akaike information criterion, and only the genotype distribution and OR under the best model are provided.
b
OR adjusted for age, sex, race/ethnicity, and study center.