Table 3.

Associations between ATM haplotypes and risk of DTC

	Haplotype	SNPa						Frequency		P	Adjusted OR (95% CI)b
		1	2	3	4	5	6	Controls (n = 855)	Cases (n = 592)
Overall
	1	T	A	C	T	C	G	0.43	0.46		1.00
	2	A	G	C	T	C	G	0.39	0.37	0.19	0.9 (0.8–1.1)
	3	T	A	C	T	C	A	0.09	0.09	0.39	0.9 (0.7–1.2)
	4	T	A	C	T	G	G	0.02	0.03	0.15	1.5 (0.9–2.4)
	5	T	G	C	T	C	G	0.02	0.02	0.14	0.6 (0.4–1.1)
	6	T	A	C	C	C	G	0.01	0.01	0.63	1.2 (0.6–2.4)
	7	A	G	C	T	C	A	0.02	0.01	0.05	0.4 (0.1–1.0)
	Othersc							0.07	0.09	0.77	0.9 (0.5–1.7)
Non-Hispanic whites
	1	T	A	C	T	C	G	0.44	0.46		1.00
	2	A	G	C	T	C	G	0.37	0.36	0.55	0.9 (0.8–1.1)
	3	T	A	C	T	C	A	0.10	0.10	0.72	0.9 (0.7–1.3)
	4	T	A	C	T	G	G	0.03	0.03	0.10	1.6 (0.9–2.7)
	5	T	G	C	T	C	G	0.01	0.01	0.22	0.6 (0.3–1.3)
	6	T	A	C	C	C	G	0.01	0.00	0.19	1.6 (0.8–3.4)
	7	A	G	C	T	C	A	0.01	0.02	0.03	0.2 (0.0–0.8)
	Othersc							0.091	0.076	0.78	1.1 (0.5–2.3)

P < 0.05 is shown in bold.

^aSNP are as follows: 1, rs228589; 2, rs189037; 3, rs1800054; 4, rs4986761; 5, rs1800057; and 6, rs1801516.

^bOR adjusted for age and sex.

^cRare haplotypes with frequencies <0.01.