Table 4.
Association between the combined risk alleles of the ATM gene and risk of DTC and PTC
| No. of risk alleles | Controls (n = 885) | DTC cases (n = 592) |
PTC cases (n = 522) |
|||||
|---|---|---|---|---|---|---|---|---|
| n | % | n | % | Adjusted OR (95% CI)a | n | % | Adjusted OR (95% CI)a | |
| 3–5 | 261 | 30.0 | 140 | 23.9 | 1.0 | 123 | 23.8 | 1.0 |
| 6–7 | 429 | 49.4 | 299 | 51.0 | 1.3 (1.0–1.7) | 261 | 50.5 | 1.3 (1.0–1.7) |
| 8–10 | 179 | 20.6 | 147 | 25.0 | 1.5 (1.1–2.1) | 133 | 25.7 | 1.6 (1.2–2.2) |
| Ptrend < 0.01 | Ptrend < 0.01 | |||||||
P < 0.05 is shown in bold.
a
OR adjusted for age, sex, race/ethnicity, and study center.