Table 2.
Anthropometric and endocrine profile of the analytical sample by menstrual regularity and serum androgensa
| Androgen status Menstrual regularity |
HA |
Normoandrogenemia |
P value | ||
|---|---|---|---|---|---|
| Oligo (n = 117) | Normal (n = 751) | Oligo (n = 208) | Normal (n = 1487) | ||
| Metabolic parameters | |||||
| BMI (kg/m2) | 30.9 (29.4, 32.6) | 28.0 (27.5, 28.4) | 27.6 (26.6, 28.6) | 26.6 (26.3, 26.9) | <0.001 |
| Waist circumference (cm) | 92.7 (89.3, 96.2) | 86.1 (85.1, 87.2) | 87.2 (84.8, 89.7) | 82.9 (82.2, 83.6) | <0.001 |
| Abdominal obesity (race specific) (%) | 57.8 (67) | 45.5 (342) | 47.1 (98) | 35.9 (533) | <0.001 |
| Hypertriglyceridemia (≤150 mg/dl) (%) | 31.3 (36) | 20.1 (149) | 18.4 (38) | 16.2 (240) | <0.001 |
| Low HDL (<50 mg/dl) (%) | 52.1 (61) | 38.3 (288) | 37.5 (78) | 33.3 (495) | <0.001 |
| HTN (SBP ≥ 130 mm Hg or DBP ≥ 85 mm Hg or meds) (%) | 42.7 (50) | 34.4 (258) | 33.7 (70) | 27.4 (408) | <0.001 |
| Impaired glucose tolerance (fasting glucose ≥ 110 mg/dl or meds) (%) | 25.0 (29) | 12.7 (94) | 11.5 (24) | 9.2 (136) | <0.001 |
| MetS (%) | 41.0 (48) | 25.7 (193) | 23.6 (49) | 17.0 (253) | <0.001 |
| High SBP (≥ 130 mm Hg) (%) | 26.5 (31) | 19.8 (149) | 22.6 (47) | 16.0 (238) | 0.003 |
| High DBP (≥ 85 mm Hg) (%) | 16.4 (19) | 19.5 (146) | 16.3 (34) | 14.0 (208) | 0.010 |
| Insulin (μIU/ml) | 10.9 (9.6, 12.3) | 9.7 (9.3, 10.1) | 9.7 (8.9, 10.7) | 9.1 (8.9, 9.4) | 0.009 |
| Glucose (mg/dl) | 106.3 (100.1, 112.8) | 96.8 (95.3, 98.3) | 95.8 (92.9, 98.8) | 93.3 (92.5, 94.2) | <.001 |
| HOMA-IR indexb | 2.8 (2.4, 3.3) | 2.3 (2.2, 2.4) | 2.3 (2.0, 2.5) | 2.1 (2.0, 2.2) | <0.001 |
| Reproductive hormones | |||||
| SHBG (nm/liter) | 36.5 (32.7, 40.8) | 38.2 (36.6, 39.7) | 36.3 (32.9, 40.1) | 39.8 (38.6, 41.0) | 0.068 |
| DHEAS (μg/dl) | 132.0 (118.6, 147.1) | 138.0 (132.4, 143.9) | 87.1 (79.7, 95.1) | 95.9 (92.5, 99.3) | <0.001 |
| Estradiol (pg/ml) | 52.4 (45.8, 59.9) | 59.7 (56.5, 63.0) | 49.5 (44.8, 54.6) | 55.1 (53.0, 57.3) | 0.006 |
| TSH (μIU/ml) | 2.1 (1.9, 2.3) | 1.9 (1.8, 1.9) | 1.8 (1.6, 1.9) | 1.8 (1.8, 1.9) | 0.021 |
| T to DHEAS ratioc | 546.4 (479.2, 622.9) | 504.3 (481.1, 528.6) | 364.5 (334.4, 397.3) | 322.6 (312.1, 333.4) | |
| FAIc,d | 6.9 (6.0, 7.8) | 6.3 (6.0, 6.6) | 3.0 (2.7, 3.4) | 2.7 (2.6, 2.8) | |
| Total T (ng/dl)c | 72.2 (68.0, 76.6) | 69.6 (68.0, 71.2) | 31.7 (30.3, 33.3) | 30.9 (30.3, 31.5) | |
HTN, Hypertension; SBP, systolic blood pressure; DBP, diastolic blood pressure; meds, medications.
a
Values in table are geometric mean (95% CI) for continuous variables or percent (n) for categorical variables.
b
HOMA-IR = (fasting insulin × fasting glucose)/22.5.
c
P values for T to DHEAS ratio, FAI, and T are omitted because the definition of HA/Oligo outcome variable includes total T.
d
Free Androgen Index = (100 × T)/(28.84 × SHBG).