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. 2012 Apr 6;97(6):E1023–E1031. doi: 10.1210/jc.2011-3432

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Copyright © 2012 by The Endocrine Society

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Fig. 1. — Body weight change over time in WT, MC4R^+/− heterozygous (Het), and MC4R^−/− null (KO) mice before and after gastric bypass surgery. A, Body weight (grams) of WT mice on a C57BL/6J background after RYGB-H (dashed green line and open green circles; n = 5) or SO (solid green line and circles; n = 5). B, MC4R^−/− mice on a 129 background after RYGB-H (dashed blue line and open blue circles; n = 3) or SO (solid blue line and circles; n = 3). C, MC4R^−/− mice on a 129/C57BL6 mixed background after RYGB (dashed blue line and open blue circles; n = 3) or SO (solid blue line and circles; n = 3). D, WT (green), Het (red), and MC4R^−/− (blue) mice on a C57BL/6J background after RYGB-C (dashed lines and open circles; n = 3, n = 4, and n = 7, respectively) or SO (solid lines and circles; n = 3, n = 6, and n = 3, respectively). E, Change in body weight (grams) from postoperative wk 4 to postoperative wk 8 in RYGB-C and SO mice. F, Body weight (grams) 8 wk after surgery in WT (left), Het (center), and MC4R^−/− (right) mice on a C57BL/6J background. Dark gray bars indicate muscle mass. White bars indicate fat mass. G, Body weight (grams) growth curves of untouched WT, Het, and MC4R^−/− mice. Error bars, sem.

Fig. 1. — Body weight change over time in WT, MC4R^+/− heterozygous (Het), and MC4R^−/− null (KO) mice before and after gastric bypass surgery. A, Body weight (grams) of WT mice on a C57BL/6J background after RYGB-H (dashed green line and open green circles; n = 5) or SO (solid green line and circles; n = 5). B, MC4R^−/− mice on a 129 background after RYGB-H (dashed blue line and open blue circles; n = 3) or SO (solid blue line and circles; n = 3). C, MC4R^−/− mice on a 129/C57BL6 mixed background after RYGB (dashed blue line and open blue circles; n = 3) or SO (solid blue line and circles; n = 3). D, WT (green), Het (red), and MC4R^−/− (blue) mice on a C57BL/6J background after RYGB-C (dashed lines and open circles; n = 3, n = 4, and n = 7, respectively) or SO (solid lines and circles; n = 3, n = 6, and n = 3, respectively). E, Change in body weight (grams) from postoperative wk 4 to postoperative wk 8 in RYGB-C and SO mice. F, Body weight (grams) 8 wk after surgery in WT (left), Het (center), and MC4R^−/− (right) mice on a C57BL/6J background. Dark gray bars indicate muscle mass. White bars indicate fat mass. G, Body weight (grams) growth curves of untouched WT, Het, and MC4R^−/− mice. Error bars, sem.