Table 2.

Biological function pathway analysis networks of hypermethylated and down-regulated genes

Biological function pathway	Score (number of other genes/hypermethylated and down-regulated genes from data sets)	Hypermethylated and downregulated genes (adjusted P < 0.01, β = 0.2; ≥ 2-fold, adjusted P < 0.05)
Drug metabolism, endocrine system development and function, lipid metabolism	38/16	ABCA1, CD55, CD74, COL4A3, GOS2, GATA6, HSD3B2, KCNQ1, MAP3K5, NCOA7, RAPGEF4, RARRES2, S100A6, SPTBN1, TNFSF13, TNS1
Lipid metabolism, small molecule biochemistry, cell cycle	27/12	ADCK3, ALDH3B1, CSDC2, CYP7B1, GIPC2, HOOK1, MEIS1, MLH3, MRPL33, NME5, RGNEF, TCIRG1
Lipid metabolism, small molecule biochemistry, energy production	21/10	AMPD3, B4GALT6, CAB39L, CD55, GYPC, NDRG4, RAB34, RBPMS, SEMA6A, TNFS1F2-TNFSF13
Cell-to-cell signaling and interaction, cellular assembly and organization, nervous system development and function	3/1	SLC16A9
Hematological disease, immunological disease, infectious disease	2/1	PHF11