Table 1.
Subject characteristics at and before enrollment (n = 71)
| Characteristics | No. missing in arms A, B, C | Treatment arm |
Pa | ||
|---|---|---|---|---|---|
| A | B | C | |||
| Dose | 2,000 IU D2 daily | 2,000 IU D3 daily | 50,000 IU D2 weekly | ||
| n | 24 | 24 | 23 | ||
| At enrollment | |||||
| Season at enrollment: winter/spring (vs. summer/fall)b | 0, 0, 0 | 83% | 75% | 91% | 0.36 |
| Subject characteristics | |||||
| Male | 0, 0, 0 | 58% | 42% | 61% | 0.35 |
| Non-Hispanic White | 0, 0, 0 | 63% | 63% | 57% | 0.89 |
| Age (yr) | 0, 0, 0 | 15.9 ± 3.0 | 14.7 ± 3.5 | 16.3 ± 3.2 | 0.23 |
| BMI Z-score | 2, 3, 0 | 0.47 ± 1.4 | 0.34 ± 0.98 | 0.40 ± 1.12 | 0.94 |
| Disease characteristics | |||||
| Diagnosis | 0, 0, 0 | 0.62 | |||
| CD | 50% | 58% | 65% | ||
| UC | 46% | 33% | 35% | ||
| IC | 4% | 8% | 0% | ||
| Months since diagnosis | 3, 5, 0 | 33 (9–45) | 7 (1–44) | 33 (14–50) | 0.24 |
| Current disease activityc | 0, 0, 0 | 0.29 | |||
| Inactive | 54% | 54% | 78% | ||
| Mild | 38% | 42% | 22% | ||
| Moderate/severe | 8% | 4% | 0% | ||
| Lifetime treatment history | |||||
| Glucocorticoids (mg) | 2, 1, 2 | 2, 145 (700–4, 000) | 1, 280 (440–2, 880) | 2, 240 (0–3, 858) | 0.59 |
| Biologics | 0, 0, 0 | 38% | 25% | 35% | 0.62 |
| Immonumodulators | 0, 0, 1 | 75% | 63% | 65% | 0.62 |
| Enteral supplementation | 0, 0, 0 | 29% | 25% | 17% | 0.63 |
| Laboratory values | |||||
| ESR (mm/h) | 0, 0, 0 | 14 (10–19) | 13 (6–17) | 11 (5–22) | 0.50 |
| CRP (mg/dl) | 0, 0, 0 | 0.2 (0.1–1.3) | 0.1 (0.1–0.2) | 0.4 (0.1–0.6) | 0.03 |
| Albumin (g/dl) | 1, 1, 0 | 4.1 ± 0.4 | 4.3 ± 0.3 | 4.2 ± 0.3 | 0.11 |
| Serum Ca (mg/dl) | 0, 2, 1 | 9.5 ± 0.5 | 9.6 ± 0.3 | 9.4 ± 0.3 | 0.21 |
| Serum P (mg/dl) | 1, 2, 2 | 4.2 ± 0.8 | 4.0 ± 0.8 | 3.9 ± 0.7 | 0.61 |
| Serum Mg (mg/dl) | 0, 2, 2 | 2.1 (2.1–2.2) | 2.2 (2.0–2.2) | 2.1 (2.1–2.3) | 0.98 |
| UCa:Ucr ≥0.2 | 2, 5, 0 | 32% | 11% | 4% | 0.04 |
| Nutrition | |||||
| Vitamin D intake (IU/d) | 1, 0, 2 | 193 (76–423) | 157 (82–518) | 355 (124–587) | 0.44 |
| Ca intake (mg/d) | 4, 2, 0 | 821 ± 390 | 887 ± 329 | 941 ± 427 | 0.60 |
| Within 1 month before enrollment | |||||
| Outdoor exposure (h/wk) | 0, 0, 0 | 5.3 (2.8–11.0) | 3.0 (2.0–5.3) | 3.0 (1.5–21.0) | 0.32 |
| Sunscreen use | 0, 0, 0 | 13% | 4% | 22% | 0.17 |
Data are expressed as percentage, mean ± sd, or median (IQR). IC, Indeterminate colitis; Ca, calcium; P, phosphorus; Mg, magnesium.
a
From Pearson χ2, Fisher exact test, ANOVA, or Kruskal-Wallis test, as appropriate for the distribution of the outcome.
b
Winter, December 22 to March 21; spring, March 22 to June 21; summer, June 22 to September 21; fall, September 22 to December 21.
c
Subjects with indeterminate colitis were handled as CD or UC according to phenotype.