Figure 2.

Recurrent and progressive rectal cancer. Arrows indicate tumour changes affecting the left sacral plexus and left sciatic nerve. (a) MRI taken three months prior to starting capecitabine, oxaliplatin and cetuximab (corresponds to MRI 2 in figure 1a). There is a presacral recurrence that extends along the left sciatic nerve. (b)MRI taken 4 months after starting capecitabine, oxaliplatin and cetuximab (corresponds to MRI 3 in figure 1b). Both the presacral recurrence and its extension along the sciatic nerve have increased in size. (c) MRI taken eight months after starting cetuximab monotherapy for analgesia (corresponds to MRI 4 in figure 1d). There is further progression of the recurrence in the presacral area and along the left sciatic nerve.