Table 2.

Association of multimarker score with risk of all-cause death, cardiac transplantation, or VAD placement

	Kaplan-Meier 1-year risk	Unadjusted	Adjusted*
Risk category†	Estimate (95% CI)	Hazard Ratio (95% CI); P value	Hazard Ratio (95% CI); P value
Low	1.6% (0.5%, 2.7%)	Referent	Referent
<–0.51‡
Moderate	6.4% (4.3%, 8.6%)	4.69 (2.92, 7.54);	3.50 (2.17, 5.67);
–0.51 to <0.52‡		< 0.001	< 0.001
High	26% (22%, 30%)	13.7 (8.75, 21.5);	6.80 (4.18, 11.1);
≥0.52 ‡		< 0.001	< 0.001

Abbreviation: CI, confidence interval

^*Adjusted for SHFM score

^†Bottom tertile of multimarker score defined as low risk, middle tertile defined as moderate risk, and top tertile defined as high risk

^‡Multimarker score calculated as 0.210 × log₂ BNP (pg/ml) + 0.176 × log₂ sFlt-1 (pg/ml) + 0.067 ×log₂ hsCRP (mg/l) + 0.274 × log₂ ST2 (ng/ml) + 0.772 × detectable TnI (vs. not) – 1.718 × log₂ uric acid (mg/dl) + 0.298 × (log₂ uric acid)² + 0.267 × log₂ creatinine (mg/dl) – 0.138 (log₂ creatinine)², where log₂ denotes log (base 2) transformation