Table 3.
Reclassification of 1-year risk of all-cause death, cardiac transplantation, or VAD placement with the addition of multimarker score to SHFM score*
| Reclassification | ||||
|---|---|---|---|---|
| SHFM score plus multimarker score | ||||
| SHFM score | 0%-<10% | ≥10%-<20% | ≥20%-<50% | ≥50%-100% |
| Events, no. (row %)† | ||||
| 0%-<10% | 22 (50%) | 19 (43%) | 3 (7%) | 0 |
| ≥10%-<20% | 4 (7%) | 30 (51%) | 26 (43%) | 0 |
| ≥20%-<50% | 0 | 6 (11%) | 41 (74%) | 8 (14%) |
| 50%-100% | 0 | 0 | 2 (19%) | 11 (84%) |
| Non-events, no. (row %)† | ||||
| 0%-<10% | 764 (88%) | 93 (11) | 15 (2%) | 0 |
| ≥10%-<20% | 121 (36%) | 154 (46%) | 60 (18%) | 1 (<1%) |
| ≥20%-<50% | 11 (9%) | 29 (23%) | 78 (62%) | 8 (6%) |
| ≥50%-100% | 0 | 0 | 2 (22%) | 5 (73%) |
| Net reclassification | |||||
| Up | Down | NRI | 95% CI | P value | |
|
| |||||
| Events† | 56 | 12 | 25.2% | (14.2%, 36.2%) | < 0.001 |
| Non-events† | 177 | 163 | -1.1% | (-5.6%, 3.4%) | 0.64 |
| Total | 24.1% | (11.6%, 36.7%) | < 0.001 | ||
Abbreviations: SHFM, Seattle Heart Failure Model score; CI, confidence interval; NRI, net reclassification index
*
Multimarker score calculated as described in Table 2
†
Number of events and non-events estimated from 1-year Kaplan-Meier risk estimates; row percentages may not sum to 100% due to estimation