Table 3.
BRCA1 and BRCA2 mutations in patients with early onset breast cancer diagnosed at ≤40 years
| Risk classification | <35 years | ≥35 years | Total | |||
|---|---|---|---|---|---|---|
| Patients no. |
Mutation no. (%) |
Patients no. |
Mutation no. (%) |
Patients no. |
Mutation no. (%) |
|
|
Early onset breast cancer ≤40 yrs only (E)* |
271 | 27 (10) | 279 | 8 (2.9) | 550 | 35 (6.4) |
| E + Bilateral breast cancer | 20 | 7 (35) | 33 | 9 (27.3) | 53 | 16 (30.2) |
| E + Breast and ovarian cancer | 0 | 0 | 1 | 1 (100) | 1 | 1 (100) |
| E + Multiple organ cancer | 5 | 0 | 14 | 1 (7.1) | 19 | 1 (5.3) |
| E + Male breast cancer | 1 | 0 | 0 | 0 | 1 | 0 |
|
E + Bilateral breast cancer + multiple organ cancer |
1 | 0 | 0 | 0 | 1 | 0 |
| Total | 298 | 34 (11.4) | 327 | 19 (5.8) | 625 | 53 (8.5) |
* p = 0.0007