Table 5.
BRCA1/2 and BRCA2 mutations according to family structure in patients with early onset breast cancer diagnosed at ≤40 years
| Age | Family structure | p value | ||
|---|---|---|---|---|
| Limited (n = 146) | Adequate (n = 92) | |||
| BRCA1/2 | ||||
| Age <35 yrs | ||||
| Mutation no. (%) |
16 11.0 |
9 9.8 |
0.77 | |
| No mutation no. (%) |
130 89.0 |
83 90.2 |
||
| Age ≥35 yrs | Limited (n = 186) | Adequate (n = 90) | ||
| Mutation no. (%) |
4 2.7 |
1 1.1 |
0.4 | |
| No mutation no. (%) |
142 97.2 |
89 98.9 |
||
| All | Limited (n = 292) | Adequate (n = 182) | ||
| Mutation no. (%) |
20 6.9 |
10 5.5 |
0.56 | |
| No mutation no. (%) |
272 93.1 |
172 94.5 |
||