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ABri1-34 oligomers are weak inducers of XBP1 splicing. (a, b) Unconventional XBP1 splicing in SY5Y cells treated with ABri1-34 oligomers, fibers and monomers at 2 μM. All the samples revealed low levels of XBP1s with no statistical differences. However, the oligomers accumulated significantly higher levels of XBP1u as confirmed by quantitation. c The S/U ratio was not significantly altered in any of the samples. *p < 0.05
