TABLE 2.
SNPs yielding significant or marginally significant associations from analysis of 111 markers in 10 FGF/FGFR genes from family based association tests for single SNPs and 2-5 SNP haplotypes in analysis of 76 MD trios and 221 Asian trios separately
| Site | Gene | SNP name | Risk allele/haplotype | % | # informative Families | T | NT | OR (95%CI) | P Value |
|---|---|---|---|---|---|---|---|---|---|
| Single SNP Analysis | |||||||||
| Asian | FGF19 | RS3737463 | 1 | 66.6 | 148 | 112 | 78 | 1.44(1.07-1.94) | 0.0136 |
| Asian | FGF19 | RS948992 | 2 | 55.4 | 148 | 114 | 83 | 1.37(1.03-1.85) | 0.0272 |
| MD | FGF19 | RS1789364 | 2 | 38.9 | 33 | 28 | 15 | 1.87(0.96-3.76) | 0.0474 |
| MD | FGF2 | RS308395 | 1 | 18.8 | 18 | 14 | 5 | 2.80(0.95-9.93) | 0.0640 |
| Haplotype Analysis | |||||||||
| Asian | FGFR1 |
RS6987534
RS6474354 RS10958700 |
2,2,1 | 12.4 | 79 | 28 | 55 | 0.51(0.31-0.82) | 0.0411 |
| Asian | FGF19 |
RS3737463
RS948992 |
1,2 | 45.1 | 145 | 117 | 82 | 1.43(1.07-1.92) | 0.0271 |
| Asian | FGF19 |
RS3737463
RS948992 RS1307968 |
1,2,1 | 45.1 | 142 | 119 | 82 | 1.45(1.09-1.95) | 0.0161 |
| Asian | FGF19 |
RS3737463
RS948992 RS1307968 RS1320706 |
1,2,1,1 | 45.3 | 142 | 116 | 80 | 1.45(1.08-1.95) | 0.0272 |
| Asian | FGF19 |
RS3737463
RS948992 RS1307968 RS1320706 RS1789364 |
1,2,1,1,1 | 36.2 | 126 | 101 | 77 | 1.31(0.97-1.79) | 0.0498 |