TABLE 3.
Maternal risk haplotypes identified by TRIMM from analysis of 28 markers in the FGF2 and FGF10 genes under an additive modelwhere maternal genotype alone (S1) controls risk to CL/P in offspring from TRIMMEST analysis in 221 Asian trios.
| Gene (#Chr) | #SNPs | Sum_logP | SNPs | Risk Allele | Estimated risk for Mat. Hap. S1 | Risk Hap Freq | χ 2 | P | ||
|---|---|---|---|---|---|---|---|---|---|---|
| 0 | 1 | 2 | ||||||||
| FGF2(4) | 12 | 0.024 | RS3789138 | 1 | 1.72 | 0.22 | 0.52 | 0.26 | 11.47 | 0.0007 |
| RS308388 | 1 | |||||||||
| RS1476214 | 1 | |||||||||
| RS1476217 | 2 | |||||||||
| FGF10(5) | 16 | 0.027 | RS10057630 | 1 | 1.61 | 0.25 | 7.29 | 0.0069 | ||
| RS1448037 | 1 | |||||||||
| RS593307 | 1 | |||||||||
| RS339502 | 2 | |||||||||
| RS1384449 | 2 | |||||||||
| RS2973647 | 1 | |||||||||