Table 4.
Comparison of Fracture Risk Calculator (FRC) hazard ratios and approximate FRAX hazard ratios (reverse calculated from the FRAX tool) for the average MrOS participant (age 74 years, BMI 27.4, and femoral neck bone mineral density [BMD] T-score -1.1).
| FRC | FRAX | |||
|---|---|---|---|---|
| Fracture estimate type | Hip 1 | Any Major 2 | Hip 1 | Any Major 2 |
| Age range, years | 45-90 | 45-90 | ||
| Race/ethnicity2 | ||||
| Black | 0.43 | 0.43 | ||
| Asian | 0.50 | 0.50 | ||
| Hispanic | 0.53 | 0.53 | ||
| Body Mass Index (BMI) | 1.6 if <21 | (1.7) 4,5 | (1.2) 4,5 | |
| BMD per unit T- or Z-score | 1.6 | 1.6 | 2.2 | 1.5 |
| Smoking (current) | 1.7 | 1.7 | 1.5 | 1.0 |
| Fracture after age 45 yr | 1.8 | 1.8 | 1.5 | 1.5 |
| Parent with hip fracture | 1.8 | 1.8 | 3.8 | 1.8 |
| Alcohol >3 units/day | 1.7 | 1.7 | 1.5 | 1.3 |
| Glucocortioid exposure | 2.3 | 2.3 | 1.7 | 1.5 |
| Rheumatoid arthritis | 1.8 | 1.8 | 1.4 | 1.3 |
| Secondary osteoporosis | (1.8)4 | (1.8)4 | (1.8)4 | (1.4)4 |
1
Hip fracture
2
Major osteoporotic fracture
3
Relative to white- (ref 19)
4
This factor is not considered in risk calculation when BMD is included
5
Per 5 unit BMI decrease