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. Author manuscript; available in PMC: 2012 Dec 1.
Published in final edited form as: Neuroscientist. 2012 Feb 24;18(5):439–451. doi: 10.1177/1073858411431646

Table 2.

Val66Met Polymorphism on Motor Learning

Author Brain Area Task Findings for Met Carriers Compared to VV Total Number of Subjects
Kleim and others (2006) Motor cortex Transcranial magnetic stimulation; finger-tapping rate, nine-hole pegboard, pinch-grip strength No motor training improvement in corticostriatal output; no increase in motor map area 78
McHughen and others (2010) Sensorimotor network fMRI; index finger training; driving-based motor learning Greater reduction of activation after index finger training; less short-term learning and poorer retention on driving-based learning 25 experiment 129 experiment 2
McHughen and others (2011) Motor cortex Transcranial magnetic stimulation; marble navigation task No cortical motor map plasticity; training overcomes deficiency 24
Fritsch (2010) — Sequential visual isometric pinch force for humans; mouse rotarod Reduced motor skill acquisition Mice showed a decreased latency to fall off 36

VV = Val/Val.