Table 2.

Initial rates of Fl-RNA cleavage and AP-RNA modification and metal-chelate reduction potentials.

Complex	Fl-RNA Cleavage Ratea (nM/min)	AP-RNA Modificationa Rate (nM/min)	Red. Potential vs. NHE of M- Chelate (mV)	Redox Couple
Cu-DOTA-Rev	0.8 ± 0.1	2.8 ± 0.1	180	2+/1+
Ni-DOTA-Rev	0.009 ± 0.008	0.323 ± 0.004	−35	2+/1+
Co-DOTA-Rev	0.063 ± 0.005	0.332 ± 0.008	142	3+/2+
Fe-DOTA-Rev	0.026 ± 0.006	0.367 ± 0.009	396	3+/2+
Cu-DTPA-Rev	0.496 ± 0.008	1.25 ± 0.04	148	2+/1+
Ni-DTPA-Rev	0.054 ± 0.008	0.169 ± 0.002	None Obs.	None Obs.
Co-DTPA-Rev	0.063 ± 0.007	0.66 ± 0.01	1111	3+/2+
Fe-DTPA-Rev	0.16 ± 0.04	0.248 ± 0.004	280	3+/2+
Cu-EDTA-Rev	0.14 ± 0.03	0.81 ± 0.01	47	2+/1+
Ni-EDTA-Rev	0.18 ± 0.05	0.524 ± 0.003	172	2+/1+
Co-EDTA-Rev	0.17 ± 0.03	0.328 ± 0.003	146	3+/2+
Fe-EDTA-Rev	< 0.02	0.109 ± 0.001	391	3+/2+
Cu-GGH-Rev	0.045 ± 0.005	0.4 ± 0.3	1038	3+/2+
Ni-GGH-Rev	0.026 ± 0.005	0.58 ± 0.01	1000	3+/2+
Co-GGH-Rev	0.003 ± 0.007	0.20 ± 0.01	−119	3+/2+
Cu-KGHK-Rev	0.060 ± 0.005	0.511 ± 0.003	1058	3+/2+
Ni-KGHK-Rev	0.043 ± 0.003	0.227 ± 0.006	1055	3+/2+
Co-KGHK-Rev	0.031 ± 0.003	0.257 ± 0.009	−228	3+/2+
Cu-NTA-Rev	2.1 ± 0.2	4.9 ± 0.2	215	2+/1+
Ni-NTA-Rev	0.067 ± 0.005	0.78 ± 0.01	176	2+/1+
Co-NTA-Rev	0.069 ± 0.003	0.99 ± 0.02	274	3+/2+
Fe-NTA-Rev	0.031 ± 0.006	0.170 ± 0.001	464	3+/2+
Background	0.015 ± 0.005	0.28 ± 0.03

^aRates above the limit of detection are shown in bold.