Figure 7. Treatment with the adenosine receptor agonist NECA reverses the increased cytokine levels caused by CD73 deletion.
CD73 WT and KO mice underwent CLP and concentrations of various cytokines were measured from blood and peritoneal lavage fluid that were obtained 16 hours post-CLP. NECA (0.03 mg/kg) was administered intraperitoneally 30 minutes before the CLP insult. The results (mean ± SEM) shown are the summary of two separate experiments (WT, n = 19; KO, n = 18). * p < 0.05 versus WT with Veh. (Vehicle, DMSO); ** p < 0.01 versus WT with Veh.; # p < 0.05 versus KO with Veh.; ## p < 0.01 versus KO with Veh.; ### p < 0.005 versus KO with Veh.