Table 1.
Physiological and pathological functions of ASICs in central nervous systems
| Function | ASIC subunit involved | Reference |
|---|---|---|
| Synaptic plasticity, learning and memory | 1a | [18;71] |
| Fear conditioning | 1a | [57;73–76] |
| Retinal integrity | 1a, 2, 3 | [58;78–80] |
| Acidosis-mediated neuronal injury | 1a, 2b | [29;38–40;60–62;64;65;67; 81–83] |
| Multiple sclerosis | 1a | [63;86] |
| Parkinson’s disease | 1a | [66] |
| Huntington’s disease | 1a | [89] |
| Depression | 1a, 3 | [90] |
| Anxiety | 1a, 3 | [91;92] |
| Epileptic seizure | 1a, 2b | [100–105] |
| Malignant glioma | 1, 2 | [108–110] |