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. Author manuscript; available in PMC: 2012 Jul 2.
Published in final edited form as: Nat Med. 2011 Jul 31;17(8):961–967. doi: 10.1038/nm.2378

Figure 6.

Figure 6

Insulin-sensitizing effects of dibenzazepine (GSI) treatment. (a) IPGTT and (b) hepatic gene expression in 16-h fasted, chow-fed lean mice following a single dose of GSI (GSI 1d) or 5 consecutive days of GSI treatment (GSI 5d). (c) Ad libitum glucose and (d) insulin levels in diet-induced obese (DIO) and ob/ob mice following a 5-day course of either vehicle or GSI. (e) IPGTT in ob/ob mice following a 5-day course of vehicle or GSI. (f) IPGTT, (g) ad lib glucose and (h) insulin levels in DIO mice treated with either vehicle or GSI every third day, or (i) every second day (arrows). (j) Western blots of Akt and IRS1 phosphorylation in livers isolated after 5 days treatment with either vehicle or GSI. *P<0.05, *P<0.01, ***P<0.001 vs. vehicle, &P<0.05 vs. GSI 1d (n = 6 each group).