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. Author manuscript; available in PMC: 2012 Jul 2.
Published in final edited form as: Bipolar Disord. 2008 Sep;10(6):726–732. doi: 10.1111/j.1399-5618.2008.00613.x

Table 1.

Demographic and clinical features of patients with treatment-emergent mania hypomania

Site Sex Age (years) Age at onset (years) Treatment at switch Maximum dose of escitalopram (mg) Dosage at switch Baseline HRSD HRSD at switch YMRS score Weeks of treatment at switch Type of switch Type of depressive episode Previous exposure to drug
Pisa F 46 44 SSRI 20 20 31 21 10 16 Hypomania Recurrent Reboxetine, fluoxetine, desipramine, trazodone clomipramine
Pisa M 46 43 SSRI + IPT 20 10 18 7 13 47 Hypomania Recurrent/atypical Paroxetine
Pisa F 30 30 SSRI 10 5 15 6 16 14 Hypomania First episode –
Pisa F 28 26 SSRI + IPT 20 20 27 23 11 10 Hypomania Recurrent/melancholic Sertraline
Pisa F 37 37 SSRI 10 5 17 2 10 17 Hypomania First episode Levosulpiride
Pisa F 27 17 IPT + SSRI 20 Venlafaxine 150 mg 20 20 15 8 Hypomania Recurrent/atypical Paroxetine
Pisa F 56 53 SSRI 5 2.5 17 11 20 3 Mania First episode/melancholic Paroxetine
Pittsburgh F 23 16 IPT – – 15 9 20 13 Hypomania Recurrent Psychotherapy + St. Johns wort

F = female; M = male; HRSD = Hamilton Rating Scale for Depression; YMRS = Young Mania Rating Scale; SSRI = selective serotonin reuptake inhibitor; IPT = interpersonal psychotherapy.