Table 3.
Multivariable-adjusteda hazard ratios (HR) and 95% confidence intervals (CI) for all-cause and specific-cause death associated with quintiles of RDW in NHANES III.
| All-cause deaths | Cardiovascular deaths | Cancer deaths | Chronic lower respiratory disease deaths |
External-cause deaths |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| RDW Quintile | RDW, median (range) |
Participant-years of follow-upb |
No. events | HR (95% CI) | No. events | HR (95% CI) | No. events | HR (95% CI) | No. events | HR (95% CI) | No. events | HR (95% CI) |
| Lowest | 12.10 (10.90–12.35) | 23,366 | 172 | (ref) | 70 | (ref) | 35 | (ref) | 3 | (ref) | 20 | (ref) |
| Second | 12.60 (12.50–12.65) | 26,248 | 302 | 1.13 (0.90–1.42) | 136 | 1.40 (0.90–2.18) | 67 | 0.84 (0.48–1.47) | 8 | 1.94 (0.48–7.81) | 20 | 0.86 (0.27–2.80) |
| Third | 12.95 (12.80–13.15) | 26,077 | 366 | 1.07 (0.85–1.36) | 162 | 1.11 (0.75–1.63) | 85 | 1.22 (0.74–2.01) | 20 | 2.74 (0.67–11.15) | 15 | 0.66 (0.21–2.12) |
| Fourth | 13.40 (13.20–13.75) | 24,478 | 500 | 1.31 (1.04–1.64) | 247 | 1.47 (1.00–2.16) | 111 | 1.31 (0.76–2.25) | 12 | 1.42 (0.19–10.39) | 18 | 0.91 (0.35–2.35) |
| Highest | 14.35 (13.80–30.60) | 24,217 | 881 | 2.00 (1.57–2.56) | 409 | 2.34 (1.50–3.66) | 188 | 1.88 (1.18–2.98) | 52 | 5.89 (1.23–28.24) | 27 | 1.07 (0.42–2.72) |
| P-trend | < 0.001 | < 0.001 | < 0.001 | 0.03 | 0.98 | |||||||
These analyses were limited to participants who had complete data on all covariates adjusted for (n = 14,310).
a
All models are adjusted for age, sex, race/ethnicity, education level, physical activity, smoking (smoking status and pack-years), and body mass index. We additionally adjusted analyses of all-cause and cardiovascular mortality for systolic blood pressure, hypertension, hemoglobin A1c, diabetes, total:HDL cholesterol ratio, hypercholesterolemia, estimated GFR, and chronic kidney disease.
b
Standardized to the United States census 1990.