Table 4.

The multivariable-adjusted^a association of RDW with all-cause mortality across certain subgroups.

	Number of participants	Number of events	Association of RDW with all-cause mortality within subgroup Hazard ratiob (95% CI)	P-interactionc
Age				0.27
< 50 years	7997	246	1.13 (1.04–1.22)
> 50 years	6313	1975	1.24 (1.18–1.31)
Sex				0.68
Male	6760	1208	1.25 (1.19–1.31)
Female	7550	1013	1.20 (1.12–1.29)
Race-ethnicityd				0.13
Non-Hispanic white	6068	1339	1.23 (1.16–1.30)
Non-Hispanic black	3850	476	1.21 (1.14–1.29)
Mexican American	3826	372	1.15 (1.07–1.24)
Smoking status				0.07
Never	7224	959	1.16 (1.07–1.24)
Former	3437	796	1.27 (1.20–1.34)
Active	3649	466	1.28 (1.17–1.39)
Diabetes				0.19
No	12783	1694	1.20 (1.15–1.26)
Yes	1527	527	1.30 (1.18–1.44)
Anemia				0.21
No	13285	1834	1.22 (1.13–1.32)
Yes	2268	652	1.16 (1.10–1.23)
Chronic kidney disease				0.51
No	12042	1569	1.21 (1.15–1.27)
Yes	1165	647	1.27 (1.19–1.35)

^aAdjusted, as appropriate, for age, sex, race/ethnicity, physical activity level, achieved education level, smoking status, pack-years of smoking, and body mass index, systolic blood pressure, hypertension, hemoglobin A1c, hemoglobin A1c, diabetes mellitus, total:HDL cholesterol ratio, hypercholesterolemia, chronic kidney disease, and estimated glomerular filtration rate.

^bHazard ratio is for a 1-standard deviation increment in RDW

^cP interaction refers to the interaction with RDW.

^dThe category of ‘Other’ was excluded due to its small size (n = 589) and heterogenous nature