Figure 3.
PC-derived DAG/TAG synthesis. Blue arrows indicate reactions involved in de novo DAG(1) synthesis. Purple arrows indicate reactions involved in PC-derived DAG(2) synthesis. PC-derived DAG/TAG synthesis may also utilize acyl editing as in Figure 4. Substrate abbreviations: DAG, diacylglycerol; G3P, glycerol-3-phosphate; LPA, lyso-phosphatidic acid; mFA, PC-modified FA; PA, phosphatidic acid; PC, phosphatidylcholine; TAG, triacylglycerol. Enzymatic reactions are underlined: A, modification of FA esterified to PC; B, reversible CPT or phospholipase C or phospholipase D/PAP DAG production. CPT, CDP-choline:DAG cholinephosphotransferase; DGAT, acyl-CoA:DAG acyltransferase; FAS, fatty acid synthesis; GPAT, acyl-CoA:G3P acyltransferase; LPAT, acyl-CoA:LPA acyltransferase; PAP, PA phosphatase; PDCT, PC:DAG cholinephosphotransferase.