Table 4.
Multivariable analysis of association between inotrope exposure and renal dysfunctiona
| Variable | Crude odds ratio | Adjusted odds ratio (95% CI) | P value |
|---|---|---|---|
| Inotrope status | |||
| Inotrope unexposed (ref) | 1.0 | 1.0 | |
| Inotrope exposed | 7.5 | 2.7 (1.5 to 4.6) | < 0.001 |
| Parsonnet score | |||
| 0 to 9 (ref) | 1.0 | 1.0 | |
| 10 to 14 | 1.5 | 1.2 (0.7 to 2.4) | 0.59 |
| 15 to 19 | 2.1 | 1.4 (0.7 to 2.9) | 0.35 |
| 20 to 29 | 3.6 | 2.3 (1.2 to 4.3) | 0.01 |
| ≥ 30 | 6.5 | 2.8 (1.3 to 6.1) | 0.007 |
| Ejection fraction | |||
| LVEF ≥ 30% | 1.0 | ||
| LVEF < 30% | 1.6 | 1.0 (0.6 to 1.7) | 0.97 |
| Intraaortic balloon pump use | |||
| No perioperative IABP use | 1.0 | ||
| Perioperative IABP use | 5.4 | 2.7 (1.6 to 4.7) | < 0.001 |
| Bypass timeb | 1.5 | 1.2 (1.1 to 1.4) | < 0.001 |
| Reoperative status | |||
| No reoperation | 1.0 | ||
| Reoperation | 4.5 | 2.3 (1.2 to 4.5) | 0.02 |
| Renal dysfunction | |||
| Normal preoperative renal function | 1.0 | ||
| Preoperative renal dysfunction | 3.7 | 1.7 (0.8 to 3.6) | 0.14 |
| Cardiac index at six hours, L/min | |||
| Cardiac index ≥ 2.2 (ref) | 1.0 | 1.0 | |
| Cardiac index < 2.2 | 1.7 | 1.0 (0.6 to 1.9) | 0.88 |
aLVEF, left ventricular ejection fraction; IABP, intraaortic balloon pump; ref, reference value; CI, confidence interval; bmodelled linearly as an increase in bypass time of 30 minutes.