Table 3.
Outcome of 76 patients with severe sepsis and septic shock according to discontinuation or not of ongoing statin therapy at ICU admission
| Discontinuation group (n = 32) |
Continuation group (n = 44) |
P value | Odds ratio (95% CI) |
|
|---|---|---|---|---|
| Invasive mechanical ventilation, n (%) | 23 (72%) | 21 (48%) | 0.03 | 0.36 (0.14-0.94) |
| Duration of invasive mechanical ventilation, days | 11 (4-18) | 6 (3-20) | 0.56 | |
| Acute Respiratory Distress Syndrome, n (%) | 13 (41%) | 8 (18%) | 0.03 | 0.33 (0.12-0.92) |
| Septic shock during ICU stay, n (%) | 24 (75%) | 23 (52%) | 0.04 | 0.37 (0.14-0.99) |
| Organ failure free days* | 6 (0-12) | 11 (6-14) | 0.03 | |
| Organ dysfunction free days* | 2 (0-10) | 10 (3-12) | 0.03 | |
| Hemodynamic failure free days * | 11 (7-13) | 14 (10-14) | 0.04 | |
| ICU length of stay, days (ICU survivors, n = 57) | 9 (4-16) | 6 (4-10) | 0.32 | |
| Hospital length of stay, days (hospital survivors, n = 54) | 36 (18-54) | 24 (12-44) | 0.09 | |
| ICU deaths, n (%) | 10 (31%) | 9 (21%) | 0.28 | 0.57 (0.20-1.61) |
| Hospital deaths, n (%) | 13 (41%) | 9 (21%) | 0.06 | 0.38 (0.14-1.04) |
CI, confidence interval.
*Organ failure free days, organ dysfunction free days, and vasoactive drug free days are calculated at day 14; Organ dysfunction was defined by a sequential organ failure assessment (SOFA) score above one for the appropriate function; Organ failure was defined by a SOFA score above two for the appropriate function.