Table 4.
Outcome of patients with severe sepsis and septic shock according to discontinuation or not of ongoing statin therapy in the propensity-matched sample
| Discontinuation group (n = 19) |
Continuation group (n = 19) |
P value | Odds ratio (95% CI) |
|
|---|---|---|---|---|
| Invasive mechanical ventilation, n (%) | 13 (68%) | 10 (53%) | 0.32 | 0.51 (0.14-1.92) |
| Duration of invasive mechanical ventilation, days | 11 (4-18) | 6 (4-31) | 0.84 | |
| Acute Respiratory Distress Syndrome, n (%) | 8 (42%) | 3 (16%) | 0.07 | 0.26 (0.06-1.19) |
| Septic shock during ICU stay, n (%) | 12 (63%) | 13 (68%) | 0.72 | 1.26 (0.33-4.84) |
| Organ failure free days* | 6 (0-12) | 9 (6-12) | 0.23 | |
| Organ dysfunction free days* | 1 (0-9) | 8 (3-11) | 0.11 | |
| Hemodynamic failure free days * | 11 (7-14) | 12 (7-14) | 0.65 | |
| ICU length of stay, days (ICU survivors, n = 27) | 10 (4-17) | 6 (5-10) | 0.42 | |
| Hospital length of stay, days (hospital survivors, n = 25) | 29 (14-51) | 20 (13-37) | 0.45 | |
| ICU deaths, n (%) | 5 (26%) | 6 (32%) | 0.72 | 1.29 (0.32-5.28) |
| Hospital deaths, n (%) | 7 (37%) | 6 (32%) | 0.73 | 0.79 (0.21-3.03) |
CI, confidence interval.
* Organ failure free days, organ dysfunction free days, and vasoactive drug free days are calculated at day 14; Organ dysfunction was defined by a sequential organ failure assessment (SOFA) score above one for the appropriate function; Organ failure was defined by a SOFA score above two for the appropriate function.