Table 3.
Diabetic | Non-diabetic | |||||||
---|---|---|---|---|---|---|---|---|
Univariate | Multivariate | Univariate | Multivariate | |||||
Variable | Estimate | P | Estimate | P | Estimate | P | Estimate | P |
Age (years) | 0.012 | NS | 0.036 | 0.04 | NS | |||
Gender | 0.464 | NS | 0.875 | NS | ||||
BMI | -0.075 | NS | -0.083 | NS | ||||
APACHE II score | 0.100 | NS | 0.124 | 0.02 | NS | |||
SOFA score * | 0.345 | 0.02 | 0.357 | 0.03 | 0.009 | NS | ||
sRAGE (pg/ml) | 0.0004 | NS | -0.00008 | NS | ||||
IL-6 (pg/ml) | 0.00003 | NS | 0.001 | NS | ||||
Thrombomodulin (ng/ml) | 0.004 | NS | 0.007 | NS | ||||
HMGB-1 (ng/ml) | -0.321 | NS | 0.046 | NS | ||||
Creatinine (μmol/L) | -0.002 | NS | 0.003 | NS | ||||
Creatinine clearance (ml/minute) | -0.0096 | NS | -0.028 | 0.01 | -0.058 | NS | ||
Blood glucose (mmol/L)* | 0.196 | NS | 0.514 | 0.003 | 0.03 | |||
PaO2/FiO2 (mm Hg) | 0.0009 | NS | -0.006 | NS | ||||
INR * | 2.753 | 0.01 | 2.328 | 0.04 | 3.176 | 0.02 | NS |
* P < 0.05 for both uni-and multivariate analysis
APACHE, Acute Physiologic Score and Chronic Health Evaluation; HMGB-1, high mobility group box-1; IL-6, interleukin-6; INR, international normalized ratio; PaO2/FIO2, ratio of partial pressure of oxygen to the fraction of inspired oxygen; SOFA, Sequential Organ Failure Assessment; sRAGE, soluble receptor for advanced glycation end-products.