Table 1.
Gene products directly repressed by miR-34a.
| Cellular process | Gene | Title | Reference |
|---|---|---|---|
| Cell cycle | CDK4 | Cyclin-dependent kinase 4 | (He et al., 2007) |
| CCNE2 | Cyclin E2 | (He et al., 2007) | |
| CCND1 | Cyclin D1 | (Sun et al., 2008) | |
| CDK6 | Cyclin-dependent kinase 6 | (Sun et al., 2008) | |
| Apoptosis/p53 pathway | BCL2 | B-cell leukemia/lymphoma 2 | (Bommer et al., 2007; Cole et al., 2008) |
| SIRT1 | Sirtuin 1, silent information regulator 1 | (Yamakuchi et al., 2008) | |
| YY1 | Ying yang 1 transcription factor | (Chen et al., 2010; Kaller et al., 2011) | |
| BIRC5 | Survivin | (Shen et al., 2012) | |
| Wnt signaling /metastasis | JAG1 | Jagged 1 | (Hashimi et al., 2009) |
| WNT1 | Wingless-related MMTV integration site member 1 | (Hashimi et al., 2009; Kim et al., 2011) | |
| NOTCH1 | Notch homolog 1, translocation-associated | (Du et al., 2012) | |
| LEF1 | Lymphoid enhancer binding factor 1 | (Kaller et al., 2011; Kim et al., 2011) | |
| WNT3 | Wingless-type MMTV integration site family member 3 | (Kim et al., 2011) | |
| CTNNB1 | Beta-catenin | (Kim et al., 2011) | |
| LRP6 | Low density lipoprotein receptor-related protein 6 | (Kim et al., 2011) | |
| MTA2 | Metastasis associated 1 family member 2 | (Kaller et al., 2011) | |
| TPD52 | Tumor protein D52 | (Kaller et al., 2011) | |
| AXL | AXL receptor tyrosine kinase | (Kaller et al., 2011; Mudduluru et al., 2011) | |
| Cancer cell stemness | MYCN | v-myc myelocytomatosis viral related oncogene N | (Cole et al., 2008;Wei et al., 2008) |
| CD44 | Heparan sulfate proteoglycan | (Liu et al., 2011) | |
| NANOG | NANOG homeobox transcription factor | (Choi et al., 2011) | |
| SOX2 | SRY (sex determining region Y)-box 2 transcription factor | (Choi et al., 2011) | |
| Mitotic signaling | MET | Met proto-oncogene (hepatocyte growth factor receptor) | (He et al., 2007) |
| MAP2K1 | Mitogen-activated protein kinase kinase 1 (MEK1) | (Ichimura et al., 2010) | |
| RRAS | Related RAS viral (r-ras) oncogene homolog | (Kaller et al., 2011) | |
| PDGFRA | Platelet-derived growth factor receptor, alpha | (Silber et al., 2012) | |
| Oncogenic Transcription | E2F3 | E2F transcription factor 3 | (Welch et al., 2007) |
| MYB | v-myb myeloblastosis viral oncogene homolog | (Navarro et al., 2009) | |
| MYC | v-myc myelocytomatosis viral oncogene homolog | (Christoffersen et al., 2009) | |
| Metabolism | ACSL1 | Acyl-CoA synthetase long-chain family member 1 | (Li et al., 2011) |
| LDHA | Lactate dehydrogenase A | (Kaller et al., 2011) | |
| IMPDH | IMP (inosine 5′-monophosphate) dehydrogenase | (Kim et al., 2012) |