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. Author manuscript; available in PMC: 2012 Jul 2.
Published in final edited form as: Hear Res. 2010 Oct 31;272(1-2):117–124. doi: 10.1016/j.heares.2010.10.010

Figure 1.

Figure 1

Capsaicin blocks IK and IK,n of OHCs from the upper third turn. A. representative currents (of 72 μM OHC) induced by step voltage commands following application of capsaicin (cap), 4-AP and BaCl2. Net currents (cap, 4-AP and Ba2+ sensitive current) are after subtraction from control (ctrl) currents in bath. The ctrl current in the figure is for capsaicin and the ctrl for 4-AP and BaCl2 are not shown here. The zero current is shown as a solid horizontal bar preceding the step currents. Representative I–V plots were produced for each original recordings B. representative I–V plots of net currents in A. The current for each voltage (V) is the 100 ms average bounded by the arrows. C. bar graph summary: 300 μM capsaicin, 300 μM 4-AP and 10 mM BaCl2 blocked outward currents at 0 mV and inward currents at −100 mV. Currents were normalized by the currents in ctrl bath. * P<0.05. D. dose response curve of capsaicin sensitive current at 0 mV (n=5). Current (ratio): currents normalized by the current at 600 μM capsaicin. E. representative recording of membrane potential with 300 μM capsaicin.