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. Author manuscript; available in PMC: 2012 Jul 2.
Published in final edited form as: Hear Res. 2010 Oct 31;272(1-2):117–124. doi: 10.1016/j.heares.2010.10.010

Figure 2.

Figure 2

Capsaicin blocks IK,n of OHCs from the lower 2nd turn. A. representative currents in control (ctrl) bath and following application of 300 μM capsaicin (cap). Net currents (ctrl-cap) are after subtraction from control (ctrl) currents in bath. B. representative I–V plots of the currents in A. C. bar graph summary: 300 μM cap blocked outward currents at 0 mV and inward currents at −100 mV. Currents were normalized by the currents in ctrl. * P<0.05. D. Effect of cap (0.1 mM) on steady-state activation curve of IK,n. Normalized tail current amplitudes versus prepulse potentials were fitted with a first-order Boltzmann function (n=6): I= Imax/(1+exp ((V−Vhalf)/S), where Imax is the fully activated current amplitude at the tail-current potential, Vhalf is the potential at half-maximal activation, V is prepulse potentials and S is the slope factors.