Figure 6.

Model of the effects of Hsp70 on tau dysfunction. Hsp70 binds soluble, monomeric tau that dissociates from microtubules, thus preventing self-association of tau into oligomeric and/or filamentous aggregates. In addition, Hsp70 also interacts with tau oligomers, ultimately preventing the formation of filamentous tau aggregates. Additionally, the association of Hsp70 with aggregated tau, particularly oligomeric tau aggregates, prevents activation of PP1 and GSK3 by the tau aggregates, preventing inhibition of conventional kinesin-dependent fast axonal transport.