Table 7: Summary of Findings From Studies Reporting on the Effectiveness of BIS Monitors To Reduce Recovery Time* (cont).
| Study (year) |
Nelskyla et al. (2001) (43) |
Guignard et al. (2001) (44) |
Pavanti et al. (2001) (45) |
|---|---|---|---|
| Study type | RCT This study hypothesized that BIS-guided anesthesia lowers the incidence and severity of postoperative nausea and vomiting and improves the time to recovery and home readiness. |
Prospective and controlled non-RCT done in 2 phases as follows: Phase 1 had 41 patients (SP) Phase 2 had 39 patients (BIS-guided anesthesia) |
RCT In the BIS group, the anesthetics were given according to a BIS value rate of 40 to 60. In the SP group, the anesthetics were given based on the anesthesiologist’s decision |
| Level of evidence | 1 | 3 | 1 |
| Study population | Women scheduled for gynecologic laparoscopy (excluding tubal ligations) | Patients undergoing various surgical procedures (hernia repair, thyroidectomy, gynecological procedures, cholecystectomy, transurethral prostatectomy, colectomy, and venous stripping) | Patients undergoing abdominal surgery |
| Number of subjects | 62 (BIS, 32; SP, 30) | 80 | 90 (45 per group) |
| Mean age, years (SD) | BIS: 32 (6) SP: 32 (6) |
BIS: 55 (14) SP: 49 (14) |
Mean: ranged from 42 to 48 |
| Premedication | Glycopyrrolate | None | Diazepam |
| Anesthetic technique | Propofol, sevoflurane, and nitrous oxide | Sufentanil, isoflurane, and propofol | Remifentanil and sevoflurane |
| Tracheal intubation | Yes | Yes | Yes |
| BIS values | Median BIS during surgery: BIS: 54 (range, 49–61) SP: 55 (range, 30–65) |
BIS: Between 40 and 60 during surgery and 60-70 during the last 15 minutes before surgery ended | Range: 40–60 |