Table 1: Level of Evidence.
| Type of Study (Design) | Level of Evidence |
Number of Eligible Studies Analyzed |
|---|---|---|
| Large randomized controlled trial, Systematic reviews of RCTs | 1 | |
| Large randomized controlled trial unpublished but reported to an international scientific meeting | 1(g) | |
| Small randomized controlled trial | 2 | |
| Small randomized controlled trial unpublished but reported to an international scientific meeting | 2(g) | |
| Nonrandomized trial with contemporaneous controls | 3 a | |
| Nonrandomized trial with historical control | 3b | |
| Nonrandomized controlled trial unpublished but reported to an international scientific meeting | 3g | |
| Surveillance (database or register) | 4a | 1 |
| Case series, multi-site | 4b | |
| Case series, single-site | 4c | 34 |
| Case series unpublished but presented to an international scientific meeting | 4g | |
| TOTAL | 35 |