Table 4. Randomized, controlled TMS studies: patient characteristics and treatment parameters.
| Study | Design | Age | Medication resistant |
Medication free |
TMS intensity |
Pulse frequency (Hz) |
Train duration(s) |
No.of trains |
Total pulses per session |
No.of sessions |
|---|---|---|---|---|---|---|---|---|---|---|
| Kolbinger et al. (1995)[1] | Parallel | 49.0 | Unknown | No | 110%MT | 0.25–0.50 | na | 1 | 250 | 5 |
| Kolbinger et al. (1995)[2] | Parallel | 49.0 | Unknown | No | 90%MT | 0.25–0.50 | na | 1 | 250 | 5 |
| Conca et al. (1996) | Parallel | 42.7 | Unknown | No | 1.9T | 0.17 | 30 | 8 | 40 | 10–14 |
| Pascual-Leone et al. (1996b)[1] | Cross-over | 48.6 | All | No | 90%MT | 10 | 10 | 20 | 2000 | 5 |
| Pascual-Leone et al. (1996b)[2] | Cross-over | 48.6 | All | No | 90%MT | 10 | 10 | 20 | 2000 | 5 |
| George et al. (1997)[1] | Parallel | 42.0 | All | 9/12 | 80%MT | 20 | 2 | 20 | 800 | 10 |
| George et al. (1997)[2] | Cross-over | 42.0 | All | 9/12 | 80%MT | 20 | 2 | 20 | 800 | 10 |
| Avery et al. (1999) | Parallel | 44.5 | All | 2/6 | 80%MT | 10 | 5 | 20 | 1000 | 10 |
| Kimbrell et al. (1999)[1] | Cross-over | 42.1 | All | 7/10 | 80%MT | 20 | 2 | 20 | 800 | 10 |
| Kimbrell et al. (1999)[2] | Cross-over | 45.1 | All | 2/3 | 80%MT | 20 | 2 | 20 | 800 | 10 |
| Kelin et al. (1999) | Parallel | 59.0 | Most | 24/70 | 110%MT | 1 | 60 | 2 | 120 | 10 |
| Loo et al. (1999) | Parallel | 48.3 | Most | 5/18 | 110%MT | 10 | 5 | 30 | 1500 | 10 |
| Padberg et al. (1999)[1] | Parallel | 51.2 | All | 2/12 | 90%MT | 10 | 5 | 5 | 250 | 5 |
| Padberg et al. (1999)[2] | Parallel | 51.2 | All | 2/12 | 90%MT | 0.3 | 8.3 | 10 | 250 | 5 |
| Stikhina et al. (1999) | Parallel | 37.5 | Some | Yes | 0.015 T | 40 | 600 | 2 | 4800 | 10 |
| Berman et al. (2000) | Parallel | Unknown | Most | Yes | 80%MT | 20 | 2 | 20 | 800 | 10 |
| Eschweiler et al. (2000) | Cross-over | 57.0 | Unknown | No | 90%MT | 10 | 10 | 20 | 2000 | 10 |
| George et al. (2000)[1] | Parallel | 44.5 | Most | Yes | 100%MT | 20 | 2 | 40 | 1600 | 10 |
| George et al. (2000)[2] | Parallel | 45.4 | Most | Yes | 100%MT | 5 | 8 | 40 | 1600 | 10 |
| Garcia-Toro et al. (2001) | Parallel | 50.8 | All | No | 90%MT | 20 | 2 | 30 | 1200 | 10 |
| Lisanby et al. (2001d)[1] | Parallel | 48.2 | Most | All recd 50 mg sertraline |
110%MT | 10 | 8 | 20 | 1600 | 10 |
| Lisanby et al. (2001d)[2] | Parallel | 45.9 | Most | All recd 50 mg sertraline |
110%MT | 1 | 1600 | 1 | 1600 | 10 |
| Manes et al. (2001) | Parallel | 60.7 | All | Yes | 80%MT | 20 | 2 | 20 | 800 | 5 |
MT, Motor threshold.
Figures within brackets following the study’s authors refer to specific comparisons within a study.
Burt T, Lisanby SH, Sackeim HA. Neuropsychiatric applications of transcranial magnetic stimulation: a meta analysis. International Journal of Neuropsychopharmacology 2002; 5(1):73-103; Subject to the copyright notice provided by Cambridge University Press, Reprinted with the permission of Cambridge University Press and the author (9)