Table 4: Patient Medication Regimens During the Studies.

Eschweller et al, 20001	All patients received constant doses of at least one antidepressant, five patients also received neuroleptics, four received benzodiazepines and two received lithium
Padberg et al, 1999	Three patients remained unmedicated. Least antidepressant was kept at a stable dose for 15 patients
George et al. 19971	Antidepressant medication tapered for 9 patients. Three patients had exper lenced a partial response to a 10 week, stable-dose antidepressant trial; these regimens were continued
Avery et al, 1999	Patients taking stable, lneffective doses of medication for at least 6 weeks continued on the same doses during the study. Patients on no medication for at least 6 weeks continued on no medication during the study
Berman et al, 2000	All patients free of antidepressants, neurolepices and benzodiazepines for the week prlor to initialising rTMS treatment, with tapers beginning earlier as necessary. Chloral hydrate given when required for lnsomnia to in-patients
Garcia-Toro et al, 2001b1	All undrewent 1 week wash out, off all medication. All patients started on sertraline (50 mg for 2 weeks, later increased, if necessery, depending on clinical response) at same times as rTMS treatment. All except two taking benzodiazepines at study entry
Garcia-Toro et al, 2001a	Patients had taken the same antidepressant medication for 6 weeks before study and continued this throughout the study
George et al. 20001	Patients free of antidepressant medications at least 2 weeks before study entry, three patients with bipolar disorder required ongoing mood stabilisers or benzodiazepins for anxiety
Kimbrell et al, 19991	Nine medication-free patients with unipolar depression; one patient with bipolar ll disorder, on lizhium; three with bipolar l disorder, one on lithium and carbamazepine one on lithium and la motrigine and one matication-free. Patients with bipolar disorder who had had previous relapes during a major depressive episode when on mood stabilisers remained on these medication
Loo et al, 1999	Five patients had antidepressants withdrawn 5 days before rTMS. Patients on steady doses of antidepressant falling to show an effect were maintained for 2 weeks before and throughout the study; nine patients received venlafaxine; four recieved nefazadone
Mosimann et al, In preparation2	Antidepressant medication not an execlution criterion. Dose stable for at least 2 weeks and no new psychoactive drug started for at least 6 weeks before the first rTMS
Klein et al, 19991	Patients:none were treatment-resistant. Patients were maintained with their previous medication regimen throughout the course of the study
Manes et al, 2001	All patients were withdrawn over 5 days form all antidepressant medications. They were durg-free 4 days before treatment
Szuba et al, 20011	Patients were free of any psychotropic medication for 7 days before study treatment(30 days fluoxetine, monoamine oxidase inhibitor antidepressants or neuroleptics)or electroconvulsive treatment in the pervious 30 days

Used with permission from the Royal College of Psychiatrists; Martin JL, Barbanoj MJ, Schlaepfer TE, Thompson E, Perez V. Repetitive transcranial magnetic stimulation for the treatment of depression: systematic review and meta-analysis. Br J Psychiatry 2003; 182:480-491