Table 9: Quality of Evidence.
| Study Design | Level of Evidence |
Number of Eligible Studies |
|---|---|---|
| Large RCT,* systematic reviews of RCT | 1 | |
| Large RCT unpublished but reported to an international scientific meeting | 1(g)* | |
| Small RCT | 2 | 11 |
| Small RCT unpublished but reported to an international scientific meeting | 2(g) | |
| Non-RCT with contemporaneous controls | 3a | 1 |
| Non-RCT with historical controls | 3b | |
| Nonrandomized study presented at international conference | 3(g) | |
| Surveillance (database or register) | 4a | |
| Case series (multisite) | 4b | |
| Case series (single site) | 4c | 1 |
| Retrospective review, modeling | 4d | |
| Case series presented at international conference | 4(g) |
*
RCT refers to randomized controlled trial; g, grey literature