TABLE 2.

ORs for Treatment Failure, Stratified According to Drainage Status

	Clindamycin	Trimethoprim-Sulfamethoxazole	β-Lactam
Drainage
Incident SSTIs, n	2270	2206	1931
Treatment failures, n (%)	107 (4.7)	246 (11.2)	215 (11.1)
Unadjusted OR (95% CI)	1.00 (reference)	2.54 (2.01–3.21)	2.53 (1.99–3.22)
Adjusted OR (95% CI)	1.00 (reference)	1.92 (1.49–2.47)	2.23 (1.71–2.90)
No drainage
Incident SSTIs, n	5189	8417	27 488
Treatment failures, n (%)	253 (4.9)	739 (8.8)	1443 (5.3)
Unadjusted OR (95% CI)	1.00 (reference)	1.88 (1.62–2.18)	1.08 (0.94–1.24)
Adjusted OR (95% CI)	1.00 (reference)	1.67 (1.44–1.95)	1.22 (1.06–1.41)

SSTIs were determined on the basis of a visit with a specific ICD-9-CM code (Supplemental Table 4) and a filled prescription for an antibiotic within 2 days. Treatment failure was defined as fulfilling the same criteria (including a new antibiotic) within 14 days after the incident event. Drainage was determined on the basis of CPT and ICD-9-CM procedure codes (Supplemental Table 4) representing incision and drainage. ORs were estimated in logistic regression analyses with adjustment for year, age, gender, race/ethnicity, and diagnosis.