TABLE 1.

Protocol Specifications of Included Trials

Study (Year)	Enrolled Patients, N	Protocol Specifications
		Gestational Age, wk	Postnatal Age at Randomization	iNO Dose, ppm	Weaning Protocol, ppma	Planned Duration of Exposure	Gas Continued After Extubation?
Subhedar et al28 (1997)	42	<32	>96 h	20→5b	—	72 h	iNO not continued after extubation
Kinsella et al25 (1999)	80	<34	<7 d	5b	—	7–14 d	iNO not continued after extubation
Srisuparp et al27 (2002)	34	<32	<72 h	20→0b	—	72 h to 7 d	iNO not continued after extubation
Schreiber et al26 (2003)	207	<34	<72 h	10→5a	10 (1 d), 5 (6 d)	7 d	In infants who were extubated within 7 d, gas was stopped 1 h before extubation
Field et al (INNOVO)23 (2005)	126	<34	<28 d	5→40b	—	48 h to 3 d	iNO stopped before extubation
Van Meurs et al29,30 (2005 and 2007)	449	<34	>4 h	5→10b	—	<14 d	iNO not continued after extubation
Hascoet et al22 (2005)	145	<32	6–48 h	5→10b	—	Up to the time when a/Ao2 increases to >0.22 (median: 28 h)	iNO not continued after extubation
Dani et al21 (2006)	40	<30	<7 d	10→6a	10 (4 h), 6 (until extubation)	81 h	iNO not continued after extubation
Kinsella et al24 (2006)	793	<34	<48 h	5a	No change	21 d	iNO stopped before extubation
Ballard et al19 (2006)	582	<32	7–21 d	20→2a	20 (48–96 h), 10, 5, 2 at weekly intervals	24 d minimum	iNO continued after extubation and after discontinuation of nasal CPAP ± oxygen
Mercier et al (EUNO)31 (2010)	800	<29	<72 h	5a	No change	7–21 d	iNO continued for 7 d or until extubation, whichever came later
Total	3298	—	—	—	—	—	—

a-Ao₂ indicates alveolar-arterial oxygen gradient; CPAP, continuous positive airway pressure.

^aNo dose change or change based on prespecified weaning protocol with fixed time points.

^bDose changes based on measured biological response in patient.