TABLE 3.
Characteristics of Study Patients Whose Condition Was Worsened at the 48-to-72–Hour Follow-up Visit
| Patient Study No. | Age, y | Gender | Study Drug | Wound Culture | Chronic Condition | Fever at Initial Visit | Location | Erythema, cm | Induration, cm | Spontaneous Drainage | Procedure | Improvement at 48–72 h |
Subsequent Procedure | Change in Antibiotics? | Hospitalized? | Secondary Outcome: Status at 7 d | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Overalla | Fever | Erythema | Pain/tenderness | Drainage | ||||||||||||||||
| 89 | 0.7 | Male | Clindamycin | MRSA | No | 101.7 | Thigh | 8 | 5 | Yes | ID-NP | 5 | 3 | 4 | 4 | 4 | Repeat ID | Yes | Yes | Resolved |
| 128 | 0.9 | Male | Cephalexin | MRSA | No | 102.7 | Buttocks | 4 | 7 | Yes | ID-NP | 1 | 3 | 4 | 2 | 4 | Wound repacked | Yes | Yes | Resolved |
| 170 | 0.9 | Female | Clindamycin | MRSAb | No | 101.3 | Thigh | 3 | 4 | Yes | EP no ID | 5 | 2 | 2 | 4 | 1 | None | Yes | No | Improved |
| 43 | 0.9 | Female | Cephalexin | MRSA | No | No | Buttocks | 6 | 5 | No | ID-P | 2 | 0 | 4 | 2 | 2 | None | Yes | No | Resolved |
| 25 | 1 | Male | Cephalexin | MRSA | No | 101.3 | Buttocks | 2 | 3.5 | No | ID-NP | 5 | 5 | 4 | 4 | 4 | Repeat ID; sedation | Yes | No | Resolved |
| 197 | 1 | Female | Cephalexin | MRSA | No | 101.5 | Groin | 6 | 5 | No | ID-NP | 4 | 3 | 5 | 3 | 3 | Repeat ID attempted | Yes | No | Resolved |
| 71 | 8 | Female | Clindamycin | MSSA | No | No | Thigh | 7 | 5 | No | ID-P | 1 | 0 | 4 | 1 | 1 | Repeat ID | Yes | No | Resolved |
| 45 | 9 | Female | Cephalexin | MRSA | No | No | Leg | 2 | 2 | No | ID-NP | 4 | 0 | 2 | 4 | 2 | None | No | No | Resolved |
| 77 | 11 | Male | Cephalexin | MRSA | No | No | Abdomen | 5 | 3 | Yes | ID-P | 2 | 0 | 4 | 1 | 2 | None | No | No | Resolved |
| Summary, median or % | 1 | 44% Male | 33% Clinda | 89% MRSA | 100% No chronic condition | 56% Fever | 100% Waist and below | 5 cm | 5 cm | 44% Spontaneous drainage | 100% Drainage procedure | 56% Repeat drainage procedure | 78% Antibiotics changed | 22% Hospitalized | 100% Improved or resolved | |||||
ID-NP indicates ID without packing; ID-P, ID with packing; EP, expressed pus.
a
Overall improvement, fever, erythema, pain/tenderness, and drainage were assessed with a 5-point Likert scale: 0, never had symptoms; 1, much improved; 2, somewhat improved; 3, unchanged; 4, somewhat worse; 5, much worse.
b
Of the 9 patients whose condition had worsened at the 48-to-72–hour follow-up, only patient 170 had a wound-culture organism that was resistant to clindamycin (it was also D-test positive).