Table 1.

Effect of NBI 27914 and non-selective CRF receptor antagonists on the latency of CRF-induced seizures

Receptor blocker	Dose (mg/kg)	Group size (n)	Latency of seizures (min)
None		23	9.96 ± 1.10
NBI 27914	0.33	7	2 = no seizures
			5 = 29.40 ± 3.53 *
	0.67	8	5 = no seizures
			3 = 30.67 ± 3.33 *
	1.0	3	2 = no seizures
			1 = 59 min latency
α-Helical CRF9–41	0.5	12	4 = no seizures
			8= 21.4 ± 4.4 *
d-Phe-CRF12–41	0.25	11	1 = no seizures
			10= 41.3 ± 11.8 *

Animals received the indicated CRF antagonist or vehicle 15–20 min prior to the infusion of 0.15 nmol of CRF, via an i.c.v. cannula. Latency and duration of seizures were scored as described in the text.

^*Statistically different from control (P < 0.001, two-tailed Mann–Whitney U- test).