Skip to main content
. Author manuscript; available in PMC: 2012 Jul 2.
Published in final edited form as: Brain Res. 1997 Oct 3;770(1-2):89–95. doi: 10.1016/s0006-8993(97)00759-2

Table 4.

Effects of NBI 27914 on urocortin-induced behavioral phenomena in immature rats

Urocortin dose (nmol) NBI 27914 n Latency of seizures (min) Seizure duration (min)
0.75 – 6 10.3 ± 2.3 98.2 ± 24.0
+ 6 2 = no seizures 18.3 ± 8.7 *
4 = 29.8 ± 13.0
0.15 – 5 1=no seizures 53.0 ± 13.5
4= 11.0 ± 3.6
+ 6 5=no seizures 0
1 = 38 10
CRF0.15 – 17 9.6 ± 1.8 125.3 ± 12.8

The CRF-related peptide, urocortin, which activates both types of CRF receptors, was given via an i.c.v. cannula, at the doses shown. The CRF1 receptor blocker abolished the convulsant effects of urocortin, indicating their mediation via CRF1.

*

Significantly different from the same dose of urocortin without NBI 27914 (P < 0.05).