Table 1.

Characteristics of subjects at baseline and 12 months by baseline diagnosis

	Baseline group
	CN		MCI		AD
Characteristic	Baseline (n = 116)	12 month (n = 93)	Baseline (n = 196)	12 month (n = 146)	Baseline (n = 89)	12 month (n = 59)
Number of women (%)	57 (49)	45 (48)	65 (33)	46 (32)	37 (42)	25 (42)
Number of APOE ε4 carriers (%)	27 (23)	22 (24)	107 (55)	80 (55)	64 (72)	46 (78)
Age, years
Median (IQR)	76 (72, 78)	76 (73, 79)	75 (70, 80)	76 (72, 81)	77 (72, 81)	79 (74, 82)
Range	62 to 90	63 to 91	55 to 89	59 to 90	65 to 89	67 to 89
MMSE
Median (IQR)	29 (29, 30)	29 (28, 30)	27 (25, 28)	27 (24, 28)	24 (22, 25)	23 (19, 25)
Range	25 to 30	25 to 30	23 to 30	17 to 30	20 to 27	5 to 27
Aβ1-42, pg/mL
Median (IQR)	221 (157, 248)	222 (160, 244)	146 (129, 201)	143 (124, 168)	140 (119, 153)	135 (125, 148)
Range	79 to 298	84 to 299	48 to 299	80 to 296	75 to 289	75 to 271
Number < 192 pg/mL (%)	47 (41)	38 (41)	145 (74)	114 (78)	82 (92)	58 (98)
Total tau, pg/mL
Median (IQR)	63 (48, 85)	67 (51, 95)	87 (64, 128)	96 (66, 139)	115 (80, 144)	115 (90, 146)
Range	29 to 200	27 to 175	28 to 463	32 to 363	32 to 349	35 to 273
Number > 93 pg/mL (%)	24 (21)	25 (27)	88 (45)	75 (51)	59 (66)	42 (71)
HVa
Median (IQR)	1.65 (1.16, 2.19)	1.53 (1.06, 2.16)	0.58 (0.03, 1.33)	0.17 (−0.41, 1.06)	−0.22 (−0.75, 0.50)	−0.65 (−1.04, 0.08)
Range	−0.34 to 3.50	−0.20 to 3.94	−1.81 to 3.81	−2.12 to 4.00	−2.00 to 1.94	−2.33 to 1.64
Number < 0.48 (%)	9 (8)	8 (9)	87 (44)	88 (60)	66 (74)	49 (83)

Abbreviations: APOE, apolipoprotein E; IQR, inter-quartile range; ADAS-Cog, Alzheimer’s Disease Assessment Scale-Cognitive Subscale; MMSE, Mini Mental State Exam; HVa, Hippocampal Volume Adjusted for Intra-cranial Volume