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. Author manuscript; available in PMC: 2013 Feb 3.
Published in final edited form as: Phys Biol. 2012 Feb 3;9(1):016001. doi: 10.1088/1478-3975/9/1/016001

Figure 1. CTC aggregates are reproducibly observed in multiple epithelial cancers.

Figure 1

CTC aggregates observed in metastatic breast (A), NSCLC (B), pancreatic (C), and prostate (D) cancer patients found by our high throughput imaging scanner were relocated and imaged by confocal microscopy for greater detail. CTCs were identified using cytokeratin antibody staining (red) with DAPI counterstain for nuclei (blue). WBCs were labeled with CD45 antibody staining (green). Lack of CD45 staining in (B) is contributed to photobleaching in a dated, archived sample. Z-projections of the images are shown here.