Table 3.
Results of Quantitative Real-Time Polymerase Chain Reaction for Major Bacterial Groups for 10 Patients Receiving Vancomycin or Fidaxomicin for 10 Days, Followed by 4 Weeks of Follow-up
|
Bacteroides |
Prevotella |
Clostridium coccoides group |
Clostridium leptum group |
Bifidobacteria |
Enterobacteriaceae |
Lactobacillus |
Enterococcaceae |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mean log10 CFU ± SD |
Mean log10 CFU ± SD |
Mean log10 CFU ± SD |
Mean log10 CFU ± SD |
Mean log10 CFU ± SD |
Mean log10 CFU ± SD |
Mean log10 CFU ± SD |
Mean log10 CFU ± SD |
|||||||||
| Day | Vancomycin | Fidaxomicin | Vancomycin | Fidaxomicin | Vancomycin | Fidaxomicin | Vancomycin | Fidaxomicin | Vancomycin | Fidaxomicin | Vancomycin | Fidaxomicin | Vancomycin | Fidaxomicin | Vancomycin | Fidaxomicin |
| 0 | 7.61 ± 2.21 | 8.52 ± 1.53 | 7.62 ± 2.17 | 8.11 ± 1.66 | 7.89 ± 1.58 | 8.17 ± 0.71 | 5.41 ± 2.21 | 5.81 ± 2.22 | 6.96 ± 0.72 | 6.35 ± 1.42 | 7.50 ± 1.70 | 7.94 ± 0.70 | 7.55 ± 0.62 | 7.62 ± 0.54 | 6.17 ± 0.51 | 5.48 ± 1.35 |
| 4 | 4.26 ± 0.88 | 7.81 ± 1.54 | 5.30 ± 0.81 | 7.84 ± 1.61 | 4.73 ± 0.53 | 6.91 ± 0.94 | 2.04 ± 0.39 | 3.53 ± 5.08 | 5.30 ± 0.81 | 5.30 ± 1.33 | 8.52 ± 1.46 | 8.81 ± 0.87 | 7.90 ± 0.45 | 7.10 ± 0.78 | 5.23 ± 0.31 | 5.75 ± 1.18 |
| 10 | 5.26 ± 0.91 | 9.33 ± 1.30 | 5.50 ± 0.92 | 8.84 ± 1.19 | 4.68 ± 0.73 | 8.49 ± 0.55 | 2.02 ± 1.31 | 5.08 ± 2.26 | 5.17 ± 1.09 | 6.28 ± 1.40 | 8.84 ± 0.57 | 7.84 ± 1.18 | 7.91 ± 0.70 | 7.64 ± 0.65 | 5.43 ± 0.36 | 5.93 ± 0.95 |
| 14 | 5.99 ± 2.10 | 9.52 ± 1.19 | 5.43 ± 1.30 | 9.06 ± 1.04 | 6.74 ± 2.21 | 8.65 ± 0.44 | 4.03 ± 1.83 | 5.29 ± 2.37 | 6.56 ± 1.43 | 6.18 ± 1.75 | 8.01 ± 1.04 | 7.98 ± 0.80 | 8.11 ± 0.43 | 7.66 ± 0.73 | 6.26 ± 0.85 | 6.07 ± 1.22 |
| 21 | 5.95 ± 2.30 | 9.30 ± 1.44 | 6.63 ± 2.21 | 8.97 ± 1.37 | 8.51 ± 0.64 | 8.73 ± 0.58 | 5.85 ± 1.21 | 5.83 ± 2.19 | 6.94 ± 0.93 | 6.06 ± 1.69 | 7.62 ± 1.03 | 7.06 ± 0.92 | 7.69 ± 0.48 | 7.34 ± 0.93 | 6.15 ± 0.67 | 6.12 ± 0.90 |
| 28 | 6.95 ± 2.87 | 9.08 ± 1.16 | 6.83 ± 2.54 | 8.93 ± 0.85 | 8.66 ± 1.11 | 8.07 ± 1.45 | 6.18 ± 1.01 | 5.82 ± 1.35 | 5.89 ± 1.19 | 6.10 ± 1.35 | 7.33 ± 1.18 | 5.95 ± 2.14 | 7.65 ± 0.55 | 7.23 ± 1.09 | 5.77 ± 0.72 | 5.79 ± 0.73 |
| 42 | 7.83 ± 1.70 | 9.34 ± 0.73 | 7.89 ± 1.63 | 9.22 ± 0.35 | 8.41 ± 0.69 | 8.40 ± 0.82 | 7.09 ± 1.33 | 6.89 ± 1.08 | 5.62 ± 1.51 | 6.11 ± 1.17 | 6.52 ± 1.61 | 6.50 ± 1.10 | 7.50 ± 0.50 | 7.60 ± 0.80 | 5.77 ± 0.76 | 5.71 ± 0.79 |