Table 2.
In Vitro Activity of Fidaxomicin, Compared With Vancomycin and Metronidazole, Against Clostridium difficile Isolates From 8 Published Studies
| MIC (μg/mL) |
|||||
|---|---|---|---|---|---|
| Drug | No. of isolates | Range | MIC50 | MIC90 | [Ref] Year/sites |
| Fidaxomicin | 16 | 0.12–0.25 | 0.25 | 0.25 | [1] 1991/US |
| Vancomycin | 0.5–1 | 0.5 | 1 | ||
| Metronidazole | 0.12–0.5 | 0.25 | 0.5 | ||
| Fidaxomicin | 207 | ≤0.001–0.625 | 0.002 | 0.008 | [4] 2004/Europe |
| Vancomycin | 0.016–0.5 | 0.5 | 0.5 | ||
| Metronidazole | 0.004–0.5 | 0.06 | 0.06 | ||
| Fidaxomicin | 23 | 0.06–2 | 0.12 | 0.25 | [5] 2004/US |
| Vancomycin | 0.5–4 | 1 | 2 | ||
| Metronidazole | 0.25–1 | 0.12 | 0.25 | ||
| Fidaxomicin | 208 | 0.06–1 | 0.25 | 0.5 | [8] 2008/Canada |
| Vancomycin | 0.5–4 | 0.5 | 1 | ||
| Metronidazole | 0.25–4 | 0.5 | 1 | ||
| Fidaxomicin | 110 | 0.015–0.25 | 0.125 | 0.125 | [6] 1983–2004/US |
| Vancomycin | 0.06–4 | 1 | 1 | ||
| Metronidazole | 0.025–0.5 | 0.125 | 0.25 | ||
| Fidaxomicin | 21 | ≤0.016–0.25 | 0.016 | 0.12 | [7] 2004/US |
| Vancomycin | 0.5–2 | 1 | 2 | ||
| Metronidazole | ≤0.125–0.5 | 0.25 | 0.5 | ||
| Fidaxomicin | 38 | ≤0.008–0.25 | … | 0.125 | [9] 2004–2005/US |
| Vancomycin | 0.25–2 | … | 1 | ||
| Metronidazole | 0.25–2 | … | 1 | ||
| Fidaxomicin | 716 | ≤0.008–1 | 0.125 | 0.5 | [10] 2005–2010/US & Europe |
| Vancomycin | 0.5–8 | 1 | 2 | ||
| Metronidazole | 0.02–4 | 0.5 | 1 | ||
Abbreviations: MIC50, minimum inhibitory concentration for inhibition of 50% of organisms; MIC90, minimum inhibitory concentration for inhibition of 90% of organisms; US, United States.