Table 3. Association analyzes between pemphigus foliaceus and HLA ligands of KIR.
KIR Ligands | Patients | Controls | ||||||
n | f (%) | n | F(%) | P | OR | 95% CI | ||
Bw4* | Euro | 64 (99) | 64.6 | 56 (71) | 78.9 | 0.045 | 0.49 | 0.24–0.99 |
Afro | 42 (64) | 65.6 | 35 (42) | 83.3 | 0.045 | 0.38 | 0.15–0.99 | |
Total | 106 (163) | 65.0 | 91 (113) | 80.5 | 0.005 | 0.45 | 0.26–0.79 | |
Bw4 80I | Euro | 57 (99) | 57.6 | 47 (72) | 65.3 | 0.307 | 0.72 | 0.38–1.35 |
Afro | 38 (64) | 59.4 | 30 (42) | 71.4 | 0.210 | 0.58 | 0.25–1.34 | |
Total | 95 (163) | 58.3 | 77 (114) | 67.5 | 0.110 | 0.45 | 0.41–1.11 | |
Bw4 80T | Euro | 15(98) | 15.3 | 16 (66) | 24.2 | 0.144 | 0.56 | 0.25–1.22 |
Afro | 5 (61) | 8.2 | 14 (41) | 34.2 | 0.001 | 0.17 | 0.06–0.53 | |
Total | 20 (159) | 12.6 | 30 (107) | 28.0 | 0.001 | 0.37 | 0.20–0.69 | |
Bw6 | Euro | 91 (96) | 94.8 | 57 (66) | 86.4 | 0.060 | 2.87 | 0.92–9.01 |
Afro | 58 (61) | 95.1 | 30 (41) | 73.2 | 0.001 | 7.09 | 1.84–27.04 | |
Total | 149 (157) | 94.9 | 87 (107) | 81.3 | <10−3 | 4.28 | 1.81–10.13 |
In parentheses, the total number of individual in the sample. Euro: predominantly European background; Afro: mixed subsample, with predominantly African background; Total: total sample. *at least one Bw4 epitope (80I from HLA-A or HLA-B loci or 80T).